DETERMINATION OF THE STARTING DOSE IN THE FIRST-IN-HUMAN CLINICAL TRIALS WITH MONOCLONAL ANTIBODIES: A SYSTEMATIC REVIEW OF PAPERS PUBLISHED BETWEEN 1990 AND 2013

Hoon Young Suh,1 Carl C Peck,2 Kyung-Sang Yu,1 Howard Lee1,3 1Department of Clinical Pharmacology and Therapeutics, College of Medicine, Seoul National University Hospital, Seoul, Korea; 2Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California, San Francisco, CA, USA; 3Department of Transdisciplinary Stud

Project cost forecasting is a complex and critical process, and it is of paramount importance for the successful implementation of engineering projects.Accurately forecasting project costs can help project managers and relevant decision-makers make informed decisions, thereby avoiding unnecessary cost overruns and time delays.Furthermore, accuratel

Many people are seeking available and effective options that are safer for people and the environment than some conventional synthetic pesticides.There is also rising interest in organic gardening, which relies on many natural pesticides.Natural products can be used in isolation or combination Vibration Sensor with conventional pesticide programs a

Abstract Blockchain technology finds widespread application across various fields due to its key features such as immutability, reduced costs, decentralization, and transparency.The security of blockchain relies on elements like hashing, digital signatures, and cryptography.However, the emergence of quantum computers and supporting algorithms poses

In the linear response eigenvalue problem arising from quantum chemistry and physics, one needs Accessory Set (5/CN) to compute several positive eigenvalues together with the corresponding eigenvectors.For such a task, in this paper, we present a FEAST algorithm based on complex contour integration for the linear response eigenvalue problem.By simp